The easiest fix for Windows users is to install a specific driver package that adds the missing legacy files back to your system without requiring a full iTunes uninstallation. Step-by-Step Instructions:
The phrase "requires iTunes 10.5 or above" is technically correct but historically misleading. In 2014, "or above" meant up to iTunes 11.1.x. Today, "above" breaks the tool because Apple deprecated the exact functions p0sixspwn relies on.
Run the p0sixspwn.exe application as an administrator. Start Jailbreak: Click the Jailbreak button. p0sixspwn requires itunes 105 or above
Run the tool natively inside the older environment. Method 2: Use a Windows Boot Camp or VM Partition
You do not necessarily need to downgrade all the way to iTunes 10. Apple released a specific version of iTunes 12.1.1 for 64-bit Windows systems that retains older, 32-bit video card and device driver compatibility. This version fixes the p0sixspwn error instantly. The easiest fix for Windows users is to
If you are using a modern macOS (Catalina, Big Sur, or newer), the original p0sixspwn tool will not run because it is a 32-bit application.
Older jailbreak tools struggle with modern USB 3.0/3.1 ports (the ones with blue tabs). Plug your device into an older USB 2.0 port, or use a USB 2.0 hub. Today, "above" breaks the tool because Apple deprecated
Download the standalone Apple Mobile Device Support MSI file. Install it alongside your current iTunes.
p0sixspwn Requires iTunes 10.5 or Above: A Comprehensive Jailbreak Guide
Why?
Interestingly, while it requires "10.5 or above," many users report that excessively new versions of iTunes (such as 12.x or later) can sometimes cause communication failures with legacy jailbreak tools on Windows.