An additional 27 media were added to the "exempt" list, meaning labs can bypass routine QC organism testing for these items.
: Requirements for physical inspection and remedial actions for deficiencies.
The primary objective of M22-A3 was to establish standardized criteria for manufacturers to validate the performance of commercial QC strains and for laboratories to verify these materials upon receipt. It focused on ensuring that reference strains (e.g., Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923) used for daily or weekly QC produce results within acceptable limits (zones of inhibition or MICs) as defined by CLSI M100. clsi m22a3 pdf
standard provides a rigorous framework for evaluating commercially prepared media. Visual Inspection Checklist:
End-user laboratories are not required to perform full, routine performance testing (growth/inhibition) on these media. Instead, they can accept the manufacturer’s Quality Control Certificate. An additional 27 media were added to the
(time, temperature, and atmosphere) for QC strains.
Understanding CLSI M22-A3: The Standard for Quality Control of Microbiological Culture Media It focused on ensuring that reference strains (e
A valid copy of the manufacturer's M22-A3 certification is accessible.
The primary purpose of CLSI M22-A3 is to establish a scientifically sound, cost-effective strategy for re-testing culture media before clinical use. It divides media into categories based on historical failure rates, allowing laboratories to streamline their workflows without compromising patient safety. Core Strategies of the M22-A3 Standard